The "Japa Syndrome," characterized by the mass migration of Nigerian professionals seeking better opportunities abroad, has significantly affected the country's health sector. This exodus of skilled health workers is driven by factors such as poor remuneration, inadequate infrastructure, etc leaving a vacuum that strains an already fragile system. The problem to be addressed in this paper is the severe impact of the "Japa Syndrome" on Nigeria’s health sector, which has resulted in a critical shortage of skilled healthcare professionals. Qualitative method was employed. In terms of technique, a systematic review process was
utilized to identify and analyze relevant literature this study. Findings reveal a critical shortage of qualified personnel, increased workload for remaining staff, and declining quality of healthcare services etc. The study recommends policy reforms that include improved remuneration, enhanced working conditions, and
investment in health infrastructure to retain skilled professionals and mitigate the adverse effects of migration. The contribution to knowledge include empiric332
framework for policy intervention, insight into workforce burnout and mental health and enhanced understanding of economic implications.